Armodafinil has been shown to have cognitive impacts in a variety of areas of the human brain, according to studies. The drug's effects have been linked to the locus coeruleus, a brain location related to emotion and motivation. The locus coeruleus is another area linked to mood and emotional activity. However, further study is required to pinpoint the precise mechanism of Artvigil 150 (Armodafinil's) action.

Analyzing the level of fos immunoreactivity in different areas of the brain is one technique to examine the neurochemical mechanism of Armodafinil's effects on the human brain. Armodafinil enhanced fos-like immunoreactivity in the cortex but not in the hippocampus or other adjacent regions, according to Lin et al. Armodafinil enhanced the amount of NE in the ventromedial preoptic region of the hypothalamus.

Armodafinil has also been proven to boost dopamine in some brain areas, notably the nucleus accumbens, in studies on mice. Moron and colleagues explored the effects of Armodafinil on the neurotransmitters norepinephrine and serotonin in recent research. These findings suggest that changes in these neurotransmitters may be responsible for the pill's influence on wakefulness.